I recently took a lab to check my warfarin levels and they are high. I want to know what an happen if they are too high and the best course of action since i havent heard back from my doctor yet. I want to know what an happen if they are too high and the best course of action since i havent heard back from my doctor yet. As your warfarin dosage increases, your INR levels will also increase. However, it is important that the INR value is not too high, as it might cause dangerous, uncontrollable bleeding. Three years ago i was dianosed with a blood clot in my left calf after treatment. I was presribed 7mg of warfarin a day with no periodic blood tests and was told i would have take warfarin the rest of my life. High INR Levels. At a high INR Level, you're at risk for internal bleeding, and your blood is thinner. A high INR Level is relative to your target INR range. Also known as warfarin, Coumadin is a blood-thinning medication. Your physician may prescribe it if you are prone to blood clots or have experienced a cardiac event like stroke or heart attack. Consumption of fruit juices, particularly cranberry or grapefruit, which inhibit warfarin metabolism, can cause INR levels to increase. These juices should be avoided. These juices should be avoided. If any of the above “red flag” features are present and an active bleed is suspected, refer to secondary care. Warfarin should be restarted, if necessary, when the INR falls below 5.0. Consideration of individual clinical parameters (eg, fall risk, blood pressure, comorbidities) and the patient’s innate sensitivity to warfarin are important when deciding when treatment should be restarted. Coumadin (warfarin) is a blood anticoagulant that inhibits the function of Vitamin K dependent coagulation used to inhibit the coagulation of blood to reduce or prevent the chance of developing heart attacks (myocardial infarctions), strokes, and venous and other blood clots (deep venous thromboses, pulmonary emboli and thrombi produced with. Vitamin K1-warfarin interaction effect. When warfarin levels are high, people have more risk of bleeding. Conversely, lower levels of warfarin lead to increased risk of blood clots. There is a narrow range where the benefits of warfarin are greater than the risks, its.